RESEARCH STUDIES                                              

 

Research supporting the "Similarities and Paradoxes in Chronic Illnesses" include but are not exclusive to Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Syndrome, Multiple Chemical Illnesses and Lyme Disease. The research supports the premise that we need more research on the infectious connections between all chronic illnesses.

 

 

 Bacterial & Viral Infections

 

       CDC: Emerging Infectious Determinants of Chronic Diseases

        http://www.cdc.gov/NCIDOD/eid/vol12no07/06-0037.htm

        CDC Perspective - Vol.12.no.7, July 2006

     

       The New Great Imitator Lyme Disease

        http://www.centuryinter.net/tjs11/bug/l2.htm

        JoAnne Whitaker, MD; Eleanor G. Fort, BG, MT: Minter H. Dopson; Lida Mattman, PhD and Sally M. Marlowe, NP

             Bowen Research and Training, Tarpon Springs, FL

 

         A Tale of Two Spirochetes: Lyme Disease & Syphilis

        http://www.mentalhealthandillness.com/Articles/ATaleOfTwoSpirochetes.htm

             JJ Halperin ,Department of Neurology, Mount Sinai School of Medicine, NY,Department of Neurosciences,  NJ

   

          A Life Cycle for Borrelia Spirochetes?

        http://www.stcatherinemedicalcenter.org/lifecyclepaper.pdf

         Alan MacDonald, AB, St. Catherine of Siena Medical Center, Department of Pathology, Smithtown, NY

      

       Understanding L-form Bacteria

        http://bacteriality.com/2007/08/15/l-forms/

        Bacteriality - Exploring Chronic Disease - Amy Proal

 

         Evidence for Bacterial ( Mycoplasm, Chlamydia) and Viral ( HHV-6) Co-      

  Infections In Chronic Fatigue Syndrome Patients

  http://www.immed.org/illness/fatigue_illness_research.html

  Garth I. Nicolson, PhD, Marwan Y. Nasralla, PhD, Kenny DeMeirleir, MD, Ph.D, Robert Gan, MB, PhD and Joerg Haier, MD, Phd  

 

        Examination of Mycoplasmas in Blood of 565 Chronic Illness Patients by

         Polymerase Chain Reaction

         http://www.immed.org/illness/fatigue_illness_research.html

         Marwan Y. Nasraala, Jorg Haier, Nancy L. Nicolson and Garth L. Nicolson, The Institute of Molecular Medicine.

 

        Studies on Gulf War Illnesses: Chronic Infections

         http://www.immed.org/illness/gulfwar_illness_research.html

         Garth Nicolson, PhD, Institute of Molecular Medicine, Huntington, CA

 

       

        Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme 

         Disease Borrelia burgdoferi:  Evidence for Mycoplasma species Co-Infections

         www.immed.org/whatsnew/...23.08updates/NicolsonIACFSabstract2.rtf

         Garth I. Nicolson, PhD, Nancy I. Nicolson, PhD. and Joerg Haier, MD, PhD, The Institute of Molecular Medicine.,

              Department of Surgery, University Hospintal, Munster, Germany

 

        Lyme Disease Presenting as Chronic Fatigue Syndrome

          http://www.prohealth.com/library/showarticle.cfm?id=7459&t=CFIDS_FM

          Samuel Shor, MD, FACP, Journal of Chronic Fatigue Syndrome

           Chronic Bacterial and Viral Infections in Neurodegenerative & Neurobehavioral

          Diseases

          http://www.medscape.com/viewarticle/574944

          Garth Nicolson, PhD - Department of Molecular Medicine, Huntington Beach, CA

      

        Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with

          Chronic Fatigue Syndrome

          http://www.nih.gov/news/health/oct2009/nci-08.htm

          Whittemore Peterson Institute, Reno, NV

 

         Multiple Sclerosis Linked to HHV-6A Virus

          http://www.hhv-6foundation.org/pressrelease_nov.pdf

               Claude Genain, PhD

 

         Chronic Lyme Borreliosis at the Root of Multiple Sclerosis - is a Cure with

          Antibiotics Attainable?

          http://www.ncbi.nlm.nih.gov/pubmed/15617845

            Clinic for Internal and Geographical Medicine, Switzerland.

 

Cancer

 

        Bacterial Infection as a Cause of Cancer

         http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518971/

         J Parsonnet       

 

        How Diarrheal Bacteria Cause Some Colon Cancers Revealed in Mouse

         Studies

         http://www.sciencedaily.com/releases/2009/08/090823184353.htm

         Johns Hopkins Medical Institution

 

         Association of Mycoplasmal Infections with Malignant Progression, Relapse &

          Stage in Breast Cancer Patients

          www.immed.org/FAQ.htm

          Garth L. Nicolson, PhD, the Institute for Molecular Medicine.

       

         

 

          Direct Visualization Propionibacteium Acnes in Prostrate Tissue by Multicolor

            Fluorescent in Situ Hybridization Assay

            http://www.ncbi.nlm.nih.gov/pubmed/17881550

            Alexeyev OA, Marklund I, Shannon B, Golovleva I, Olsson J, Andersson C,

                 Eriksson I, Cohen R, Elgh F.

 

Alzheimer's

 

               Alzheimer's Study Leads to Better Drug for Infections

            http://www.medicalnewstoday.com/articles/172132.php

                 Matthew R Chapman, PhD - Washington University,  St. Louis, MO          

 

               Plaques of Alzheimer's Disease Originate from Cysts of Borrelia burgdorferi

            the Lyme Disease Spriochete.

            http://www.medscape.com/viewarticle/574944_8

            Alan MacDonald, St. Catherine of Siena Medical Center, Department of

                 Patholgy, Smithtown, NY

 

 Autism

 

                The Association between Tick-borne Infections, Lyme borreliosis and Autism

                  Spectrum Disorders

             http://www.lymebook.com/med-hypothesis-article.pdf

                   Robert C. Bransfield, Jeffrey S. Wulfman, William T. Harvey, Anju I. Usman, Department of Psychiatry,

                   Riverview Medical Center, Red Bank, NJ.

 

 

           Think Tank to Examine Link Between Autism and Lyme Disease

             http://www.topcoderblogs.com/a131808-think-tank-to-examine-link-between.cfm

             The Lyme Induced Autism Foundation holding physician's Think Tank in San Diego, CA - recent findings

 

Neurologic  

 

                 Chronic Neurologic Manifestations of Lyme Disease

             http://www.ncbi.nlm.nih.gov/pubmed/2172819

              EL Logigian, RF Kaplan, and AC Steere    

 

            Neurologic Manifestaions of Lyme Disease in the Pediatric Populations

             http://library.lymenet.org/domino/file.nsf/bbf2f15334c1f28585256613000317cc/c8237a2ae855ba  c6852567c700120021?OpenDocument

              Dorothy Pietrucha, MD, FAAP

 

            Lyme - Associated Parkinsonism:  A Neuroopathologic Case Study & Review

             of the Literature

             http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043%2F1543-2165(2003)127%3C1204:LPANCS%3E2.0.CO%3B2

             David s. Cassarino, MD, PhD, Martha M. Quezado, MD, Nitya R Ghatak, MD

                   and Paul H. Duray, MD

 

            

           Researchers Identify Cell Group Key to Lyme Disease Arthritis

            http://www.sciencedaily.com/releases/2008/12/081203184920.htm

            Research Team at La Jolla Institute for Allergy and Immunology and Albany Medical College

                      

Inflammation

 

           Fibroymalgia, Chronic Fatigue syndrome, and Multiple Chemical Sensitivities

            http://www.drmirkin.com/morehealth/g115.htm

            Gabe Mirkin, MD

 

           Inflammation and Central Nervous System Lyme Disease

            http://www.ncbi.nlm.nih.gov/pubmed/11558789

            Brian A. Fallon, Elizabeth S. Levin, Pernilla J. Schweitzer, David Hardesty

                  Department of Psychiatry, Columbia University, NY

                         

            New Immune Cell Found to be a Key to Inflammatory Diseases

             http://www.eurekalert.org/pub_releases/2005-10/uotm-nic093005.php

      University of Texas M.D. Anderson Cancer Center

 

            Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease - Role of

             Spirochetes

             http://www.ncbi.nlm.nih.gov/pubmed/18487847

             Journal of Alzheimer's Disease - Judith Miklossy, University of British

                   Columbia, Kinsmen Lab of Neurological Research, Vancover, BC, Canada

 

            Microglia Are Mediators of Borrelia burgdorferi - Induced Apoptosis in SH-   

             SY5YNeuronal Cells

             http://www.plospathogens.org/article/info:doi%2F10.1371%2Fjournal.ppat.1000659         

                   Terenance A. Myers, Deepak Kaushal, Mario T. Philipp - Divison of bacteriology & Parasitology, Tulane National

                   Primate Research Center, Tulane University Health sciences Center, Louisiana

 

 

            High Prevalence of 'Borrelia-like' Organisms in Skin Biopsies of Sarcoidosis

             http://www.novoseek.com/DocumentDetailAction.action?docId=19469874&corpus=MEDLINE

             Derler, AM, Eisendle K. Baltaci M, Obermoser G. Zelger B., Dept. of Dermatology and Venerology, Innsbruck

                   Medical University, Innsbruck, Austria

 

Micro-organisms

 

            An Association Between Sciatica and Micro-organisms

             http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)05109-6/abstract

             Professor TSJ Elliott, A Stirling MD, P.Lambert, MD, T. Worthington, MD.

                   M. Jiggins MD. - University Hospital, Birmingham, UK, Royal Orthopaedic

                   Hospital, Birmingham, UK, Aston University, Brimingham, UK

 

            

 

 

          Morgellons disease, illuminating an undefined illness:  a case series.

            http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737752/

            William T Harvey, Robert C. Bransfield, Dana E. Mercer, Andrew J Wright,

                  Rebecca M. Ricchis and Mary M. Leitao, Preventive Medicine, Red Bank, NJ

 

Depression

 

           Lyme, Depression, and Suicide

            http://www.mentalhealthandillness.com/Articles/LymeDepressionAndSuicide.htm

            By Robert C. Bransfield, MD, Red Bank, NJ

 

                 Late-Life Depressive Symptoms Are Associated With Both Hyperactivity and

             Hypoactivity of the Hypothalamo-Pituitary - Adrenal Axis

             http://journals.lww.com/ajgponline/Abstract/2007/06000/Late_Life_Depressive_Symptoms_Are_Associated_With.9.aspx

             Brenda W.JH Penninx, PhD, Aartjan T.F. Beekman, MD, PhD, Stepbania Bandinelli, MD.,Anna Maria Corsi, PhD

 

 Autoimmune

 

            Infections and Autoimmune Diseases       

             http://www.direct-ms.org/pdf/InfectiousMS/Bach%20Infections%20and%20autoimmunity%20review.pdf

                   Bach, JF, Laboratoire d'Immunologie, Hopital Necker, Paris, France

 

                 Autoimmune Disease in the era of the Metagenome

             http://autoimmunityresearch.org/transcripts/AR-Proal-Metagenome.pdf

             Amy D. Proal, Paul J. Albert, Trevor G. Marshall, Georgetown University, Weill Cornell Medical College,

                   Murdoch University

 

            Bacterial Triggers and Autoimmune Rheumatic Diseases

             http://www.ncbi.nlm.nih.gov/pubmed/18570749

                   Girschick HJ, Guilherme L, Inman RD, Latsch K, Rihl M, Sherer Y, Shoenfeld Y, Zeidler H, Arienti S, Doria A.

                    Pediatric Rheumantology, Immunology, Infectious Diseases, Children's Hospital, University of Wuerzburg,

                    Germany

 

            Evidence of Borrelia Autoimmunity - Induced Component of Lyme Carditis &

             Arthritis

             http://jcm.asm.org/cgi/content/abstract/43/2/850

             Elizabeth S. Raveche, Steven E. Schutzer, Helen fernandes Helen Bateman, Brian A. McCarthy, Steven P.

                    Nickell, and Madeleine W. Cunningham, Department of Pathology and Medicine, New Jersey, UMDNJ, 

                    Newark, NJ, Dept. of Molecular Genetics and Microbiology, UNM, Albuquerque, NM, and U of Oklahoma

                    Health and Science Center, Oklahoma City, Oklahoma.

 

What can the clinical state of an infection mimic?

 

*  Multiple sclerosis

 

*  Amylotrophic lateral sclerosis ( ALS)

 

*  Alzheimers Disease

 

*  Parkinsons Disease

 

*  Thyroid Disease

 

*  Hyperparathyroidism

 

*  Lupus

 

*  Rheumatoid Arthritis

 

*  Polymyalgia Rheumatica

 

*  CFIDS

 

*  Fibromyalgia

 

*  Multiple Chemical Sensitivity

 

*  Bipolar

 

*  Addisons Disease

 

(Lyme Borreliosis causes, mimics, is manifested as, is misdiagnosed as ,or is a contributing factor to over 300 medical conditions. ( Dr. D. Klinghardt, MD, PhD )